LIFE SCIENCES, ANALYTICAL & MEDICAL TECHNOLOGIES

Equipment Applications for Dissolution Testing

Principle & OEM Spectroscopy Components

Dissolution Testing

Dissolution testing measures the rate at which a specific element, in this case a tablet, capsule, pill or even ointment, dissolves into a liquid. Understanding how a drug dissolves is important to characterize its effectiveness once taken by patients.

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Dissolution Methodology and Testing

Dissolution Testers provide controlled and repeatable environments to run tests. Testing relies on sampling the liquid solutions in the vessels at regular intervals and measuring the concentration of the dissolved analyte by UV-VIS spectroscopy measurements or by HPLC. Spectroscopy measurements can be achieved by taking the liquids out of the vessels or by bringing the light in with in-situ fiber optics probes.

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Multi-channel Solutions for In-Situ Fiber Optics Dissolution Testing

tec5's exclusive Electronics & Fiber-based Hardware Multiplexers have been designed for applications requiring the simultaneous or sequential acquisition of multiple channels, such as in multi-vessels dissolution testers. Thanks to tec5’ E-MUX, up to 8 MMS spectrometers can be simultaneously acquired with a single electronics, optimizing design simplicity and total cost of ownership.

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    FAQ

    Frequently Asked Questions at tec5USA

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    Typical applications include white light interference for thin film analysis, UV absorption of proteins for quantitative analysis, colorimetry, impurity detection in water, cleaning validation for API manufacturing, polymerization inhibitor monitoring, electroplating bath monitoring....

    The spectroscopic methodology is determined by which parameters are important to monitor during a process. For example, if you want to monitor protein concentration in a bioreactor, in which the biosynthesis takes place in an aqueous medium, then you likely would want to use Raman spectroscopy for the application, as water does not contribute to the Raman signal. Alternatively, if moisture content is important, water has very strong absorption in the NIR due to several vibrational and combination modes that can be monitored; water is transparent in the UV and visible spectral region. Understanding which chemical is important as there could be various factors that influence the choice of methodology....

    NIR spectroscopy is utilized across a variety of industries for qualitative and quantitative product analysis. Typical industries include Chemistry, Pharmacology, Food Feed & Beverage, Agriculture, and others. NIR spectroscopy is well suited for species containing C-H, N-H & O-H bonds, making it a wide-range technology for a variety of applications such as moisture, fat, oil, alcohol, APIs, polymers, etc....

    Raman spectroscopy is a technique which is used for several markets. These industries include Oil and Gas, Pharmacology, Biotechnology, Petrochemistry and many others. Due to the high selectivity of Raman spectroscopy, it is a powerful tool for many applications including, hydrocarbon analysis, bioreactor protein monitoring, crystallization monitoring, API concentration, polymer identification, surfactant analysis, natural gas components and several others....

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