PHARMACOLOGY & BIOTECHNOLOGY

Virus Detection

Introduction

In clinical diagnostics, Surface Enhanced Raman Scattering (SERS) and Localized Surface Plasmon Resonance (LSPR) have emerged as significant advancements, especially for rapid detection of pathogens like SARS CoV-2.
 
SERS improves upon Raman spectroscopy by using metal nanostructures to boost scattering, facilitating the detection of minute quantities of biological molecules. Meanwhile, LSPR utilizes the optical properties of nanoparticles to detect changes in the local refractive index, essential for identifying biomolecules. The integration of these technologies into portable Point-of-Care (POC) devices represents a major leap forward, offering benefits like real-time analysis and non – invasive testing.

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Surface Enhanced Raman Scattering (SERS)

Surface Enhanced Raman Scattering (SERS) is a key advancement in spectroscopic diagnostics, crucial for rapidly detecting viruses like SARS COV-2 Building upon traditional Raman spectroscopy, SERS amplifies the Raman scattering effect using metal nanostructures, enabling the detection of tiny biological molecule amounts, essential for early viral detection Metallic nanoparticles, especially gold and silver, enhance this effect due to their plasmonic properties. SERS stands out in clinical diagnostics for its heightened sensitivity and specificity, quick results, non-invasive, label-free detection, and adaptability to various biological samples. Its primary use is in identifying pathogens, including SARS CoV-2, from diverse samples, underscoring its vital role in disease detection and pandemic management.

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Localized Surface Plasmon Resonance (LSPR)

Localized Surface Plasmon Resonance (LSPR) is an innovative optical technique that detect a viral presence with high precision by monitoring changes in the local refractive index near metal nanoparticles. When viral particles bind to these carefully engineered nanoparticles, causes a measurable shift in the resonance wavelength, indicating infection (Figure 3). LSPR’s exceptional sensitivity allows for the detection of SARS COV-2 at early stages, vital for effective containment Its rapid and real-time analysis capabilities provide a significant advantage over conventional methods, making LSPR a transformative tool for non-invasive diagnostics and a comerstone for modem clinical practices in disease monitoring and management.

Handheld POC Device

The handheld SERS immunoassay device is a groundbreaking tool in clinical diagnostics, hamessing Raman spectroscopy to decipher molecular structures in biological samples. It operates by directing laser light onto a sample. then analyzing the energy of the resultant scattered light. Key to its efficacy is a carefully designed substrate containing Silver Nanorods, enhancing sample capture and analysis. This device incorporates a meticulous approach to preparing
samples, acquiring spectra, and processing data. It utilizes advanced computational models for accurate diagnostics, ensuring precision and reliability. This sophisticated method enables efficient, detailed analysis, marking a significant advancement in rapid, on-site clinical testing.

Key Benefits

The handheld SERS immunoassay Point-of-Care (POC) device leverages Raman spectroscopy to decipher biological samples molecular structures. Its substrate, featuring Silver Nanorods, is key for accurate molecule detection. This device ensures precision through a process of sample preparation, incubation, and advanced spectral analysis. Able to handle multiple samples efficiently, it offers rapid, non-invasive testing, enhancing diagnostic speed, reliability, and
convenience.

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    FAQ

    Frequently Asked Questions at tec5USA

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    Typical applications include white light interference for thin film analysis, UV absorption of proteins for quantitative analysis, colorimetry, impurity detection in water, cleaning validation for API manufacturing, polymerization inhibitor monitoring, electroplating bath monitoring....

    The spectroscopic methodology is determined by which parameters are important to monitor during a process. For example, if you want to monitor protein concentration in a bioreactor, in which the biosynthesis takes place in an aqueous medium, then you likely would want to use Raman spectroscopy for the application, as water does not contribute to the Raman signal. Alternatively, if moisture content is important, water has very strong absorption in the NIR due to several vibrational and combination modes that can be monitored; water is transparent in the UV and visible spectral region. Understanding which chemical is important as there could be various factors that influence the choice of methodology....

    NIR spectroscopy is utilized across a variety of industries for qualitative and quantitative product analysis. Typical industries include Chemistry, Pharmacology, Food Feed & Beverage, Agriculture, and others. NIR spectroscopy is well suited for species containing C-H, N-H & O-H bonds, making it a wide-range technology for a variety of applications such as moisture, fat, oil, alcohol, APIs, polymers, etc....

    Raman spectroscopy is a technique which is used for several markets. These industries include Oil and Gas, Pharmacology, Biotechnology, Petrochemistry and many others. Due to the high selectivity of Raman spectroscopy, it is a powerful tool for many applications including, hydrocarbon analysis, bioreactor protein monitoring, crystallization monitoring, API concentration, polymer identification, surfactant analysis, natural gas components and several others....

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